Research Article | Open Access
Volume 2021 - 1 | Article ID 191 | http://dx.doi.org/10.51521/JSCRR.2021.1101
Academic Editor: John Bose
PRIYABRATA PANDA1,*, SAHIL MOHAMMAD2, PALLAVI
DIKSHIT3
1Kanak Manjari
Institute of Pharmaceutical Sciences, Rourkela, Odisha, India
2Utkal
University of Pharmaceutical Sciences, Bhubaneswar, Odisha, India
3Birla Institute
of Technology, Mesra, Ranchi, India
Corresponding Author: Priyabrata Panda, Kanak Manjari Institute of
Pharmaceutical Sciences, Rourkela, Odisha, India; Telephone:+91-9963678792;
Email: priyabrata.panda.rockstar@gmail.com
Citation: Priyabrata
P, Sahil MD, Pallavi D (2021) 13-cis-Retinoic Acid: It’s Therapeutic
Implications and Adverse Effects. J Skin Care Res Rep, 1(1);1-8
Copyright: © 2021, Priyabrata P, Sahil MD, Pallavi D. This is an
open-access article distributed under the terms of the Creative Commons
Attribution 4.0 International License, which permits unrestricted use,
distribution and reproduction in any medium, provided the original author and
source are credited.
ABSTRACT
Isotretinoin (13-cis-retinoic acid) is a second-generation
synthetic retinoic acid analog beneficial for the treatment of recalcitrant
nodulocystic acne. 13-cis-retinoic acid is also used to treat oral leukoplakia
and has shown mixed results in cancer therapy. It is a much safer drug but can
cause severe side effects like teratogenicity, dryness of the skin (including
eyes, tongue, mouth, and nasal mucosa), rashes on the face and body, itching,
increased photosensitivity, bleeding from the nose (epistaxis), lip
inflammation (cheilitis), bleeding & inflammation of gums (gingivitis), and
depression & suicidal ideation in patients. It is a schedule H drug and is
contraindicated in pregnant women. This review article gives a complete understanding
of the pharmacology of Isotretinoin along with the completed clinical trials
and research on Isotretinoin for treating other diseases apart from acne and
oral leukoplakia. The article also deals in measures to prevent the
adverse effects related to 13-cis-retinoic acid.
KEYWORDS:
Retinoids, Isotretinoin, Retinoic acid receptors, Acne, Oral leukoplakia, Teratogenic effect, Mucocutaneous effect, Triglycerides, Psychological effect, Cancer therapy, Clinical trials, Schedule H drug.
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