Research Article | Open Access
Volume 2023 - 3 | Article ID 234 | http://dx.doi.org/10.51521/IJFMPH.2023.3110
Academic Editor: John Bose
ONI OLUWATOSIN IDOWU1,*,
AJOMOLE FLORA OLUFUNKE1, OMONIYI OLATUNJI1, ODESANMI
TAYELOLU MARY2, RAJI HABEEBAT MOTUNRAYO1, OGUNGBEJE
AANUOLUWAPO1.
1Neglected Tropical Diseases, Ondo State Primary Health Care
Development Agency, Oke-Eda, Akure.
2Public Health Department, University of Medical Sciences,
Ondo, Ondo State, Nigeria
Corresponding Author: Oluwatosin Idowu Oni, Neglected Tropical Diseases, Ondo State Primary Health
Development Agency, Oke-Eda, Akure, Email: godsprince805@gmail.com; Phone:
+2348032943456
Citation: Oni Oluwatosin Idowu, Ajomole
Flora Olufunke, Omoniyi Olatunji, Odesanmi Tayelolu Mary, Raji Habeebat
Motunrayo, Ogungbeje Aanuoluwapo. (2023) Efficacy of Praziquantel and Schistosomiasis Reinfection Rate among
School-Aged Children in Ondo State, Nigeria; How Feasible is the WHO 2030
Elimination Roadmap?. Int J Fam Med Pub Health, 3(1);1.-5
Copyrights: © 2023, Oni Oluwatosin Idowu, et
al., This is an open-access article distributed
under the terms of the Creative Commons Attribution
4.0 International License, which permits unrestricted use, distribution and
reproduction in any medium, provided the original author and source are
credited.
ABSTRACT
Background:
Schistosomiasis,
caused by blood flukes of the genus Schistosoma that depend on snail
intermediate hosts for their life cycle, is a neglected tropical parasitic
disease of great public health and socioeconomic significance. Most studies on
Schistosomiasis are only prevalence data and not purposefully conducted for
interventional programmes. There is a need to access the possible intervention
impact as the Nation moves towards the elimination of Schistosomiasis. This
study was designed to assess the prevalence and efficacy of PZQ and post-treatment
reinfection among SAC and adolescent population in an endemic Community (Ayadi,
Irele Local Government Area, Ondo State, Nigeria).
Methods: A cross-sectional
study was conducted among 140 School Aged Children (SAC) and adolescents at
Ayadi, Irele 3 Local Government Area of Ondo State, Nigeria.
Results: The prevalence of
Schistosomiasis at baseline was 65% which dropped to 12.01% following 4 weeks
post-treatment and unfortunately out of the participants that tested positive
at baseline and negative at 4 weeks post-treatment with PZQ, 13.75% of them
already got infected 6 months post PZQ single use. A significant Egg Reduction
Rate (86.49%) and Cure Rate (87.91%) were obtained in this study.
Conclusion: Treatment with a
single dose of 40 mg/kg of PZQ produced a significant result against
Schistosomiasis. However, there was a high reinfection rate due to the lack of
safe water.
Recommendations:
The Schistosomiasis elimination program
should be redesigned to accommodate double dose treatment with PZQ and also
ensure treatment across all endemic wards without having to sectionalize
treatment across moderately and lowly endemic wards.
KEYWORDS: Schistosomiasis, Praziquantel, Prevalence, Cure rate, Egg Reduction Rate, Reinfection Rate.
.png)
.jpg)
.gif)
.jpg)
