Research Article | Open Access
Volume 2021 - 2 | Article ID 184 | http://dx.doi.org/10.51521/JPEM.2021.2209
Academic Editor: Mari Uyeda
Yogesh
Zambare, Shraddha Shinde, Vaibhav Gawade, Pavan Chinchole
1Department of Pharmaceutical Quality
Assurance Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research,
Pimpri, Pune-411018, India, Email : zambare007@gmail.com
2Department of Pharmaceutical Quality
Assurance Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research,
Pimpri, Pune-411018, India, Email : shraddhashinde9625@gmail.com
3Department of Pharmaceutical Chemistry,
Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune
411018, India, Email: gawadevaibhav6060@gmail.com
4Department of Pharmaceutical Chemistry Dr.
Rajendra Ghode College of Pharmacy, Amravati, Email :pavanchinchole@gmail.com
Corresponding
Author: Dr. Zambare.
Y.B., Assistant Professor, Pharmaceutical Quality Assurance,
Dr. D.Y. Patil Institute of Pharmaceutical Sciences & Research. Email: zambare007@gmail.com Mob. 91 9766845044.
Citation: Yogesh
Z, Shraddha S, Vaibhav G, Pavan C (2021) A Review On Clinical and
Therapeutic Management of Gestational Diabetes Mellitus (GDM). J Pharm Exper
Med, 2(2);1-6.
Copyright: © 2021, Dr. Zambare. Y.B. This is an
open-access article distributed under the terms of the Creative Commons
Attribution 4.0 International License, which permits unrestricted use,
distribution and reproduction in any medium, provided the original author and
source are credited.
ABSTRACT:
A high-performance
thin-layer chromatographic method was developed and validated for estimation of
AzilsartanKamedoxomil in pharmaceutical dosage form. The proposed method was
applied successfully to the pharmaceutical analysis of the recently approved
dosage form of AzilsartanKamedoxomil which is available in market as a brand
name of Edarbi 40 tablets. The drugs were satisfactorily show peak with RF 0.58
for AzilsartanKamedoxomil. Method was validated according to the ICH
guidelines. Accuracy and precision of the proposed method was evaluated by
recovery studies (% recovery for Azilsartan Kamedoxomil was 99.49 %) and
intra-day and inter-day precision studies. In stability testing, Azilsartan Kamedoxomil
were found susceptible to acid hydrolysis and alkaline degradation. Because the
method could effectively separate the drugs from their degradation products, it
can be used as a stability indicating method. The proposed validated stability
indicating assay for the sensitive determination of the mentioned drugs is
suitable for Quality control laboratories as a simple fast economic method.
Degradation product of AzilsartanKamedoxomil in alkaline condition was carried
out and its degradation product is successfully separated and isolated by HPTLC
method. degradation product was identified by using MS-MS technique.
KEYWORDS:
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