Research Article | Open Access
Volume 2022 - 1 | Article ID 216 | https://dx.doi.org/10.51521/IJGHE.2022.1104
Academic Editor: John Bose
GREGORIO RANGEL1*, RATANA LEKSOMBOON2,3*
AND SURASAK WANRAM
1Department of Biomedical Laboratory Science, Dili Health
Science Institute, Timor-Leste
2College of Medicine and Public Health, Ubon Ratchathani
34190, Thailand
3Center for Excellence in Biomedical Sciences and Engineering,
Ubon Ratchathani 34190, Thailand
*Corresponding
author: Gregorio Rangel., Department of
Biomedical Laboratory Science, Dili Health Science Institute, Timor-Leste,
Emil: gregoriorangel20@gmail.com
Citation: Gregorio Rangel*, Ratana
Leksomboon and Surasak Wanram, (2022) Impact of Plasmodium falciparum Malaria on Liver and Red Blood Cell. Int J
Gastroenterol Hepatol Endosc, 1(1);1-4.
Copyright:
© 2022, Gregorio Rangel. This is an
open-access article distributed under the terms of the Creative Commons
Attribution 4.0 International License, which permits unrestricted use,
distribution and reproduction in any medium, provided the original author and
source are credited.
ABSTRACT
Malaria
remains one of the greatest public health challenges worldwide, particularly in
tropical and sub-tropical countries. Estimates about 212 million and 429.000
death per year worldwide. The liver and red blood cell (RBC) are the organ that
has clearly changed in the early stages of infection. The aim of this study was to elucidate the inflamed sinusoidal area
showing the change of liver morphology in severe Plasmodium falciparum (P.
falciparum) malaria infection and red blood cell anatomical changes. P.
falciparum malaria invasion associated with endothelial activation and
expression of adhesion molecules. Some infected RBCs can be eliminated by the
host immune system. However, some carry on infection which leading to severe
malaria. Decrease deformability of erythrocyte infected by malaria parasites
may play a role of enrichment in the liver. The different sizes and shapes of
infected RBC in the liver were resulted diversity morphological of RBCs and
their function in the infected organs
KEYWORDS: Tropical
diseases, Parasitology, Malaria, P. falciparum, Red blood cells, liver and pathophysiology
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