Research Article | Open Access
Volume 2024 - 1 | Article ID 254 | http://dx.doi.org/10.51521/JMTCCR.2024.11102
Academic Editor: John Bose
Kaitlyn Lizardo, MD, Mackenzie Brown,
MD, S Aaron Ralston, DO
Kaitlyn Lizardo, MD, 1500 S Main Street, Fort Worth, TX 76104, Email: klizardo@jpshealht.org
Mackenzie Brown, MD, 1500 S Main Street, Fort Worth, TX 76104, Email: Mbrown12@jpshealth.org
S Aaron Ralston, DO, 1500 S Main Street, Fort Worth, TX 76104, Email: aralston@ies.healthcare.org
Corresponding Author: Kaitlyn Lizardo, MD, 1500 S Main Street, Fort Worth, TX 76104, Email: klizardo@jpshealht.org
Citation: Kaitlyn Lizardo, MD, Mackenzie Brown, MD, S Aaron Ralston, DO (2024). Lamotrigine Overdose Causing Seizure and Apnea with Rapid Clinical Improvement: A Case Report. J Med Toxicol Clin Case Rep, 1(1),1-3.
Copyright: © 2024; Kaitlyn Lizardo, et al., This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Abstract
Lamotrigine is a common medication used for bipolar disorder and seizure prophylaxis. An overdose on less than a month's supply of low dose Lamotrigine can result in significant morbidity. In this case report, we detail the instance of a 25-year-old male who overdosed by consuming a 20-day supply of his prescribed lamotrigine, amounting to approximately 4 grams in total. The patient arrived approximately 90 minutes post-ingestion, displaying symptoms of nystagmus and mild fatigue. Within the subsequent two hours, seizures and apnea emerged, necessitating intubation. Effective treatment was administered, and the patient had symptom resolution within 12 hours. The patient's symptoms correlated with the expected time to peak serum concentration; however, his rapid resolution is at odds with previously measured elimination half-lives of lamotrigine. This case contributes to the existing literature on a relatively uncommon but possibly rising overdose occurrence. It also emphasizes the clinical importance of delineating the trajectory of symptom manifestation and resolution and advocating for additional scrutiny of the anticipated clinical progression.
Keywords: Apnea, Lamotrigine, Overdose, Seizure, Toxicity
.png)
.jpg)
.gif)
.jpg)
