Research Article | Open Access
Volume 2025 - 3 | Article ID 294 | http://dx.doi.org/10.51521/WJMRR.2025.3207
Academic Editor: John Bose
Bhaskar Chakraborty and Sushma Tamang Pradhan
Organic Chemistry Laboratory, Sikkim Government College (NBBGC), Gangtok 737102, Sikkim, India, E-mail: bhaskargtk@yahoo.com
Corresponding Author: Bhaskar Chakraborty, Organic Chemistry Laboratory, Sikkim Government College (NBBGC), Gangtok 737102, Sikkim, India.
Citation: Bhaskar Chakraborty* and Sushma Tamang Pradhan (2025) Mechanochemical Synthesis and Potential Anticancer Activities of Fluoro Isoxazolidine & Isoxazoline Derivatives Derived from N-Substituted-4-(Trifluoromethyl)-C-Phenyl Nitrones. World J Multidiscip Res Rev, 3(2);1-8.
Copyright: © 2025, Bhaskar C, Sushma T.P., This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Abstract:
The present study reports solid phase synthesis of some N-Substituted-4-(Trifluoromethyl)-C-phenyl isoxazolidine and isoxazoline derivatives following green chemistry protocol and screened for anticancer activity against a panel of four human cancer cell lines. Among newly synthesized molecules, molecule 2 and 4 have shown IC50 of 0.01, 0.5 and 0.3 µM against HeLa, MDA-MB-231, MCF-7, A549 respectively. The isoxazolidine derivative 4 has also found to be concentration dependent inhibitory activity against NF-kB (nuclear factor kappa-light-chain-enhancer of activated B-cells) with 55% inhibition in 24 hr at 10 µM. This solvent free mechanochemical procedure procedure with the addition of sodium bicarbonate showed remarkably faster reaction rate and enhanced workup process as well as yields of the reported fluoronitrones and fluoro cycloadducts compared to microwave and coventional cycloaddition procedures.
Keywords: Mechanochemistry, intermolecular cycloaddition reaction, fluoro isoxazolidine & isoxazolines, anticancer activity
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