Research Article | Open Access
Volume 2025 - 4 | Article ID 268 | http://dx.doi.org/10.51521/IJFMPH.2025.41115
Academic Editor: John Bose
Dr. Sagam
Dinesh Reddy, Dr. Sateesh Babu Kaki, & Dr. Sarath Chandra Nibhanpudi
Dr. Sagam Dinesh Reddy, LMR Hospital, G Konduru, NTR District, Andhra
Pradesh, India, Email: dineshsagam143@gmail.com, ORCID: 0000-0001-7659-9441
Dr. Sateesh Babu Kaki, Tejaswi Hospital, Mylavaram, NTR District, Andhra
Pradesh, India, Email: sateeshbabu100@gmail.com
Dr. Sarath Chandra Nibhanpudi, SVMC, Tirupati, Andhra Pradesh, India Email: nschandra82@gmail.com
Corresponding
Author: Dr. Sagam
Dinesh Reddy, LMR Hospital, G Konduru, NTR District, Andhra Pradesh, India,
Email: dineshsagam143@gmail.com
Citation: Dr. Sagam Dinesh Reddy, Dr. Sateesh Babu Kaki, & Dr. Sarath Chandra Nibhanpudi (2025) Serum Uric Acid Levels and Dengue Severity: A Comprehensive Meta-Analysis. Int J Fam Med Pub Health, 4(1);1-4.
Copyrights: © 2025, S. Dinesh
Reddy, Sateesh B.K, & Sarath C.N., This is an open-access article
distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution
and reproduction in any medium, provided the original author and source are
credited.
ABSTRACT
Background: Dengue fever is a major public health concern, with some patients progressing to severe dengue, characterized by plasma leakage, organ impairment, and hemorrhagic manifestations. Serum uric acid (SUA) has been proposed as a potential biomarker for disease severity. This systematic review and meta-analysis evaluates the association between SUA levels and dengue severity. Methods: A systematic search was conducted in PubMed, Scopus, Web of Science, Embase, Cochrane Library, Google Scholar, MedRxiv, and BioRxiv from January 2000 to January 2025. Studies reporting SUA levels in severe and non-severe dengue cases were included. A random-effects meta-analysis was performed to estimate pooled risk ratios (RR) and mean differences (MD) with 95% confidence intervals (CIs). Heterogeneity was assessed using the I² statistic, and publication bias was examined via funnel plot and Egger’s test. Results: A total of 11 studies with 1,880 participants were included. The pooled RR for severe dengue in patients with elevated SUA levels was 1.32 (95% CI: 1.12–1.52, p < 0.05). Heterogeneity was low to moderate (I² = 10.07%), suggesting consistency among studies. Egger’s test detected significant publication bias (p = 0.034). Subgroup analyses by region and age group confirmed robustness of the findings. Conclusion: Elevated serum uric acid levels are significantly associated with increased dengue severity. SUA may serve as a predictive biomarker for severe dengue, aiding in early risk stratification. Further prospective studies are warranted to confirm these findings.
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