Research Article | Open Access
Volume 2021 - 1 | Article ID 205 | http://dx.doi.org/10.51521/IRJCPT.2021.1110
Academic Editor: Pragathi Reddy
GIDDLA LEELA JACOB1,
KUDIPUDI HARINADHA BABA2
1M.Pharm
Assistant Professor, Rajeev Gandhi College of Pharmacy, Andhra Pradesh, India.
2Principal,
Narayana Pharmacy College, Nellore, Andhra Pradesh, India.
Corresponding
author: Giddla Leela Jacob, Assistant
Professor, Rajeev Gandhi College of Pharmacy, Andhra Pradesh, E-mail address:
giddlaleelajacob@gmail.com
Citation:
Giddla Leela Jacob, Kudipudi Harinadha
Baba (2021)
Antidiabetic Antioxidant and Hematological Effect of
Ethanolic Extract of Muntingia Calabura on Streptozoticin Induced Diabetic
Rats. Int Res J Clin Stud Pharm Trends. 1(2),1-5.
CopyRight:
© 2021, Irripothu Paula Preethi, Yetigadda Vamsi Priya, Sunkara Hima Bindhu,
Dr.Kudipudi Harinadha Baba. (2021). This is an open-access article distributed
under the terms of the Creative Commons Attribution 4.0 International License,
which permits unrestricted use, distribution and reproduction in any medium,
provided the original author and source are credited.
ABSTRACT
Diabetes has emerged as major problem
International Diabetes Federation (IDF), there have been an estimated 40
million persons with diabetes in India in 2007 and this number is predicted to,
rise to almost 70 million people by 2025. Fresh stem bark of muntingia calabura
was collected, in Tadepalligudem in the plant was identified and authenticated
by Dr D.V Swamy Professor in, Horticulture Dr YSR Horticulture university. The
bark of muntingia calabura was peeled out from stem and was washed cleanly. The
bark muntingia calabura was air-dried to 10 days for constant, weight in room.
About 750 grams of bark was collected. Thirty male wistar 200-250 gms rats,
were randomized in to five groups consisting six animals in each group.
Streptozotocin is used as an agent to induce diabetes mellitus by selective
cytotoxicity effect on pancreatic beta cells. Thus it affects endogenous
insulin release and as a result increases blood glucose level. Streptozotocin
was confirmed in this study in relation to the normal control rats. Long term
reduction of this parameter may result in internal and external haemorrhage and
finally leads to death. However, after plant extract administration, the level
of platelet was improved markedly especially at the dose of 100 mg/kg while
that of 200 mg/kg did not have strong effect as compared with diabetic
untreated rats. This effect indicated the ability of the plant extract to
stimulate the biosynthesis of clotting factors due to the presence of active
muntingia calabura.
KEYWORDS:
Antidiabetic, Antioxidant, Haemotological, Streptozoticin
and Muntingia Calabura.
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