Research Article | Open Access
Volume 2021 - 1 | Article ID 213 | http://dx.doi.org/10.51521/IRJCPT.2021.1301
Academic Editor: John Bose
N.L. SUCHARITHA1, P. SUJALA1,
Dr. K. ANUSHA2, Dr. D. KRANTHICHAITHANYA3
1Pharm. D, Santhiram College of Pharmacy, Nandyal, A.P. India.
2Asst. professor, Department of pharmacy practice, Nandyal, A.P. India
3MBBS, MD, DM, Department of cardiology, Santhiram Super Speciality
Hospital and Medical College, Nandyal, A.P. India.
Corresponding Author: N.L. Sucharitha; Pharm. D, Santhiram College of Pharmacy, Nandyal,
A.P. India. Email: sucharitharockzz@gmail.com.
Citation: N.L. Sucharitha, P. Sujala, Dr. K.
Anusha, Dr. D. Kranthichaithanya (2021). Comparison
of the Efficacy of Atorvastatin and Rosuvastatin in Patients diagnosed as
Coronary Artery Disease [CAD]: An Observational Prospective Study. Int Res J
Clin Stud Pharm Trends, 1(3);1-5.
Copyright: © 2021, N.L. Sucharitha, P. Sujala,
Dr. K. Anusha, Dr. D. Kranthichaithanya (2021). This is an open-access
article distributed under the terms of the Creative Commons Attribution 4.0
International License, which permits unrestricted use, distribution and
reproduction in any medium, provided the original author and source are
credited.
ABSTRACT:
Aim and objective of the study is to
compare the Efficacy of Atorvastatin and Rosuvastatin in CAD patients based on
Lipid profile and to enhance the compliance of patients. It is a prospective
comparative study conducted between July 2018-January 2019. A Total of 124
patient’s lipid profile data case forms of age 25 years and above were
collected and two follow ups were performed with a time gap of 45 days for each
follow-up and efficacy of Atorvastatin-40mg and rosuvastatin-20mg was compared.
Among the total no. of cases collected the lipid profile parameters were
analysed for each individual patient. The efficacy of Atorvastatin-40mg was
compared with Rosuvastatin 20mg and the mean differences of both the drugs were
calculated. mean differences for both drugs were calculated. The mean
differences of LDL cholesterol for Atorvastatin were 64.469 and Rosuvastatin
was 72.683. The Mean differences of HDL Cholesterol for Atorvastatin was 22.172
and for Rosuvastatin was 32.950. Triglycerides mean difference for Atorvastatin
was 124.172 and Rosuvastatin was 198.100. Total Cholesterol mean differences
was 48.125 for Atorvastatin and for Rosuvastatin was 59.471. Our study
concludes that the drug compliance was seen in both the patients using
Atorvastatin 40mg and Rosuvastatin 20mg.But based on the mean differences and
P-Valves calculated for the lipid profile parameters of each individual
patient, Rosuvastatin 20mg has more efficacies with fewer side effects when
compared to Atorvastatin40mg.
KEYWORDS: Coronary Artery Disease, Lipid profile, Statins, Efficacy.
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