Research Article | Open Access
Volume 2025 - 3 | Article ID 272 | http://dx.doi.org/10.51521/JPEM.2025.e31115
Academic Editor: John Bose
Sumbul Rehmana, Mohd
Harisb*, and Abdur Raufc
aResearch Scholar (Unani Pharmacology), bAssistant
Professor, cAssociate Professor, Department of Ilmul Advia
(Unani Pharmacology), Faculty of Unani Medicine, Aligarh Muslim University,
Aligarh-202002 INDIA.
Corresponding Author: Mohd Haris, Assistant Professor, Department of Ilmul Advia (Unani
Pharmacology), Faculty of Unani Medicine, Aligarh Muslim University,
Aligarh-202002 INDIA.
Citation: Sumbul Rehman, Mohd Haris*, and Abdur Rauf (2025) Efficacy of Powder
and Hydroalcoholic Extract of Pharmacopoeial Formulation in Ethanol-Induced
Gastric Ulcer in Rats. J Pharm Exper Med, 3(1);1-7.
Copy Rights: © 2025, S Rehman, M Haris*, A Rauf. This is an open-access article
distributed under the terms of the Creative Commons Attribution 4.0
International License, which permits unrestricted use, distribution and
reproduction in any medium, provided the original author and source are
credited.
Abstract
Gastric ulcer is a major public health
problem globally and associated with severe complications including
haemorrhages, perforations, gastrointestinal obstruction, and malignancy. Dawa-e-Sahaj (DS)
is a notable Pharmacopoeial formulation used to treat stomach-related
ailments in Traditional Unani medicine. However, its efficacy has to be
established through scientific validation. The aim of the study was to
determine the gastroprotective effects of powder test drug (PTD) and
Hydroalcoholic extract (HAE) extract of Dawa-e-Sahaj (DS)
against ethanol-induced gastric ulcer in rats. Ulceration was induced by a
single oral administration of ethanol (0.5 ml/100 g body weight). Wistar rats
were pre-treated with ranitidine (standard drug) at a dose of 30
mg/kg/day body weight, PTD and HAE at 616.66 mg/kg and 92.49 mg/kg body
weight respectively once daily for 7 days prior to ulcer induction. At the end
of the experiment, gastric secretions and antioxidant parameters were
evaluated. The obtained data was statistically analysed using GraphPad Prism
8.0.2 software. We observed that the significantly increased (p < 0.05)
ulcer index, gastric volume, malondialdehyde
and myeloperoxidase level were effectively reduced following
treatment with PTD and HAE of Dawa-e-Sahaj. The PTD and HAE also
markedly attenuated the reduced activity of superoxide dismutase3 and
prostaglandin E2 as well as pH in the ulcerated rats. These findings are
indicative of gastroprotective and antioxidative potentials of the PTD and HAE
of Dawa-e-Sahaj which is also evident in the degree of % inhibition against
ulceration. The available data in this study suggest that the PTD and HAE
extracts of Dawa-e-Sahaj proved to be capable of ameliorating
ethanol-induced gastric ulceration due to its antioxidant potential and
presence of bioactive molecules.
Keywords: Antacid, Antioxidative, Dawa-e-Sahaj, Ethanol induced gastric
ulcer, Unani medicine
.png)
.jpg)
.gif)
.jpg)
