Research Article | Open Access
Volume 2022 - 1 | Article ID 212 | http://dx.doi.org/10.51521/IRJCPT.2021.1312
Academic Editor: John Bose
SYED HABIBUNNISA1, SANGARAJU THANUJA1, MELAM QUEENI SHAROON1, SYED NAYAB RASOOL1, KATTI BHARATHI1, DR. KUDIPUDI HARINADHA BABA2
Corresponding Author: Syed Habibunnisa, Pharm.D, Narayana College of Pharmacy, Andhra Pradesh, habisyed1998@gmail.com
1Pharm.D, Narayana Pharmacy College,
Andhra Pradesh, India, 524003.
2Principal, Narayana Pharmacy College, Nellore, Andhra Pradesh, India, 524003.
Citation: Syed Habibunnisa, Sangaraju Thanuja, Melam Queeni Sharoon, Syed Nayab Rasool, Katti Bharathi, Kudipudi Harinadha Baba (2021). Antidiabetic Antioxidant and Hemotological Effect of Ethanolic Extract of Muntingia Calabura on Streptozotocin Induced Diabetic Rats. Int Res J Clin Stud Pharm Trends, 1(3);1-4.
Copyright: © 2021, Syed Habibunnisa, Sangaraju Thanuja, Melam Queeni Sharoon, Syed Nayab Rasool, Katti Bharathi,Kudipudi Harinadha Baba (2021). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
ABSTRACT:
Antimicrobial peptides (AMPs) are a class of small peptides that widely exist in nature and they are an important part of the innate immune system of different organisms. Lysostaphin is a 27 KDa glycylglycine endopeptidase, an antibacterial enzyme which is capable of cleaving the crosslinking pentaglycine bridges found in the cell wall peptidoglycan of certain Staphylococci. Lysins are being used as antibacterial agents due to their high effectiveness and specificity in comparison with antibiotics, which are susceptible to bacterial resistance. A few of the peptidoglycan hydrolases such as lysostaphin (AAB53783.1), enterolysin (AGG79281.1), and endolysin (YP_009901016.1) were selected for the study based on an extensive text mining process. The present study identified AMPs from the antimicrobial proteins mentioned above and their properties were further assessed. In silico prediction tools identified lysostaphin, enterolysin and endolysin to harbour 3, 2 and 1 peptide molecules respectively. Out of three peptides of lysostaphin 2 were found to exhibit antibiofilm property and one was found to exhibit antifungal property. Antimicrobial peptides are that widely exist in nature and they are an important part of the innate immune system of different organisms, with a wide range of inhibitory effects against bacteria, fungi, parasites and viruses. They have been shown to have a broad spectrum of activity which ranges from anti-bacterial, anti-viral, anti-parasitic etc. The major class of peptides is as follows: cationic peptides, anionic peptides, cationic amphipathic peptides, host defense peptides, alpha helical peptides.
KEYWORDS: Antidiabetic, Antioxidant, Haemotological, Streptozoticin and Muntingia Calabura.
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