Osho P.O*¹, Ojo M.A², Okunnuga N.A³, Oyeneyin A.O⁴, Oni O.I⁵, Ojo-Rowland M⁶, Balogun E.M⁷, Ojo-Rowland O.T⁸

¹Department of Hematology and Blood transfusion, University of Medical Sciences Teaching Hospital, Ondo City, Ondo State, Nigeria.

²Department of Hematology, Gurayat General Hospital.Al jouf. Saudi Arabia

³Department of Radiology, University of Medical Sciences Teaching Hospital, Ondo City, Ondo State, Nigeria.

⁴Department of Community Health Science, University of Medical Sciences, Ondo City, Ondo State, Nigeria.

⁵Department of Neglected Tropical Diseases, Ondo State Primary Health Care Center, Ondo City, Ondo State, Nigeria

⁶Department of Obstetrics and Gynecology, State Specialist Hospital, Ondo City, Ondo State, Nigeria.

⁷Department of Nursing Science, University of Medical Sciences, Ondo City, Ondo State, Nigeria

⁸Department of Medicine and Surgery, University of Ilorin, Ilorin, Kwara state, Nigeria

Corresponding author: Dr. Osho Patrick^*, Department of Hematology and Blood transfusion, University of Medical Sciences Teaching Hospital, Ondo City, Ondo State, Nigeria, Email: droshopo@gmail.com, droshopo@unimed.edu.ng

Citation: Osho P.O*, Ojo M.A, Okunnuga N.A, Oyeneyin A.O, Oni O.I, Ojo-Rowland M, Balogun E.M, Ojo-Rowland O.T, (2024). Outcome of Multiple Myeloma in the Elderly with the use of Bortezomib in Comparison to Old Combination Therapy in UNIMED Teaching Hospital, Southwest Nigeria: 2 Case Reports and Literature Review. J Oncol Res Case Rep. 1(2),1-5.

Copyright: © 2024, Osho P.O*, Ojo M.A, Okunnuga N.A, Oyeneyin A.O, Oni O.I, Ojo-Rowland M, Balogun E.M, Ojo-Rowland O.T. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

ABSTRACT:

Multiple myeloma is a B-cell neoplasm resulting from proliferation of monoclonal plasma cells in the bone marrow characterized by hypercalcemia, bone lesions, renal impairment and anaemia which causes a monoclonal protein secreting disorder call paraproteinemias. Globally, it is known to be a disease of the elderly with a median age incidence of 65 in the western countries and 58 years in Sub-Saharan Africa, it is of rare occurrence in young adults. The significance of this disease in the elderly is being emphasized in this case report showcasing two elderly patients, an 86-year old female and a 79-year old male, both being managed for the past 12 and 5 years respectively. The patients were investigated and diagnosis of multiple myeloma was made using bone marrow aspiration, plasmacytosis >30%, Full blood count, Peripheral blood film, protein electrophoresis, ESR and X-rays findings. The 86-year old woman was placed on old combination therapy; while the 79-year old man was placed eventually on bortezomib-combination therapy, and both of them have shown tremendous improvement in their treatments over the period of time they were being managed. We put forward this case report and literature review for better understanding of this disease in elderly and how different therapies have been introduced to improve their health and survival outcome in our environment.

KEYWORDS: Multiple Myeloma, Bortezomib, Combination Therapy, Elderly